Precision mass measurements are performed at the mass spectrometer ISOLTRAP with a relative mass uncertainty routinely reaching to 1*10^-8. The time-of-flight detection technique is employed to determine the frequency of an ion stored in a Penning trap, from which the mass can be extracted. The system has studied nuclides with half-lives below 100ms and production yields of less than 1000 ions per second, supplied by the isotope separator ISOLDE at CERN. The nuclides investigated range from light systems - such as 17Ne - to heavy ones - such as 233Fr, thus, giving insight into numerous physics topics, e.g., to probe nuclear structure and answer questions related to stellar nucleosynthesis or fundamental tests.